Gout patients less likely to develop Alzheimer’s

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Researchers have found that gout may have a protective effect on brain and those suffering from this most common inflammatory arthritis may be less likely to develop Alzheimer’s disease.

Researchers say that the uric acid that can crystallise to cause gout may protect against Alzheimer’s, they wrote in the online journal Annals of the Rheumatic Diseases. Gout happens when excess uric acid builds up in the blood, causing crystals to form around the joints, inflicting extreme pain and swelling.

Testing a theory that antioxidant properties in uric acid may protect the brain, a team led by experts at Division of Rheumatology, Allergy, and Immunology at Massachusetts General Hospital, and at Boston University Medical Center, in Boston, USA looked at the records of 3.7 million people over the age of 40 in a British database of medical charts.

Researchers compared data on people with gout, and those without, who developed Alzheimer`s disease in a followup period of about five years. The researchers identified 309 new cases of Alzheimer’s among 59,224 gout sufferers with an average age of 65, and 1,942 cases among 238,805 non-sufferers.

This amounted to a 24 per cent lower risk of Alzheimer`s disease for people with a history of gout, after factoring in differences in age, gender, bodyweight, lifestyle and health.

“Our findings provide the first population-based evidence for the potential protective effect of gout on the risk of AD (Alzheimer`s disease) and support the purported neuroprotective role of uric acid,” the authors said in a statement.

“If confirmed by future studies, a therapeutic investigation that has been employed to prevent progression of PD [Parkinson’s disease] may be warranted for this relatively common and devastating condition.”